Inhibition of Aurora A Kinase with VX-680 reduces invasiveness of nasopharyngeal carcinoma

Researchers have found that the invasiveness of nasopharyngeal carcinoma can be reduced by inhibition of Aurora A Kinase with VX-680.

GSK scientists publish AurA/TPX2/VX-680 co-crystal structure

Researchers from GSK have published the co-crystal strucuture of Vertex’s Aurora A kinase inhibitor VX-680 in combination with TPX2/Aurora A

Sorafenib and Bevacizumab combination therapy increases antitumor activity

Combining Sorafenib and Bevacizumab has been shown to increase antitumur activity in patients with advanced solid tumors, especially those with ovarian cancer.

Inhibition of IKK2 blocks IL-1beta induced collagen degradation

Administration of IKK-2 inhibitor [5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxamide (TPCA-1) to rabbit corneal fibroblasts blocks IL-1-induced collagen degradation

Retrospective study shows imatinib treatment induces hypogammaglobulinemia

A retrospective study of 72 chronic myeloid leukemia and 15 gastrointestinal stromal tumor patients has shown that patients developed a significant reduction of gammaglobulin and immunoglobulin serum levels.