Sirolimus found to cause veno-occlusive disease (VOD)

Sirolimus has been found to cause veno-occlusive disease (VOD) after TBI-based transplantation, and this is potentiated by concomitant methotrexate administration

E Mercks Matuzumab effective in pancreatic cell lines/models

E Mercks Matuzumab (EMD72000) reduced ErbB-1 phosphorylation and downstream MAPK and AKT signaling in vitro. In vivo the drug induced tumor cell apoptosis in a dose-dependant manner.